Men with erectile dysfunction (ED) have a nearly 3-fold greater risk for also having open-angle glaucoma (OAG) than men with normal erectile function, according to an article published in the January issue of Ophthalmology.
Pathologic mechanisms common to ED and OAG may include the components of the metabolic syndrome (hypertension, decreased insulin sensitivity, dyslipidemia, and obesity) and their effects on inflammatory, vascular, and endocrine abnormalities, the authors suggest.
These findings implicate OAG as a potential sentinel symptom for vascular disease in men with ED. The study suggests that OAG and ED appear to have a common mechanism of endothelial dysfunction related to nitric oxide.
For their study, the investigators drew on longitudinal data from a health insurance database to identify 4605 men older than 40 years who had newly diagnosed ED (International Classification of Diseases, Ninth Revision, Clinical Modification, code 607.84), as well as 23,025 control patients (5 for each case patient).
If these findings are confirmed, ED will become a risk factor for glaucoma, with recommendations for ocular evaluation in patients with ED.